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目的:中药谷神冲剂是我院研制的治疗慢性萎缩性胃炎药物。今观察其对胃泌酸功能及癌胚抗原的影响。方法:用五肽胃泌素法检测谷神冲剂治疗萎缩性胃炎前后胃泌酸功能变化情况,用单克隆抗体试剂检测其胃液癌胚抗原(CEA)、蛋白质(PQA)含量。结果:用谷神冲剂治疗后胃泌酸功能明显得到恢复,正常酸者明显增加,差别显著(P均<0.01),与维酶素组对照,其治愈率、总有效率有显著差异(P均<0.01),且CEA、PQA均较治疗前减低。结论:谷神冲剂可恢复胃酸分泌功能,降低胃液癌胚抗原,改善胃内酸碱环境,具有双向调节作用,无毒副作用。
Purpose: The traditional Chinese medicine Gushen Granules is a medicine for the treatment of chronic atrophic gastritis developed in our hospital. We will observe its effect on oxyntic acid function and carcinoembryonic antigen. Methods: Gastrin was used to detect the changes of oxyntic acid function before and after treatment of atrophic gastritis with pentagastrin, and the content of carcinoembryonic antigen (CEA) and protein (PQA) in gastric juice was detected by monoclonal antibody reagent. RESULTS: Gastric oxyntic function was significantly restored after treatment with Gushen granules, and normal acid levels were significantly increased (P<0.01). Compared with the riboflavin group, the cure rate and total effective rate were significantly different (P<0.05). All <0.01), and CEA, PQA were reduced before treatment. Conclusion: Gushen granules can restore gastric acid secretion, reduce carcinoembryonic antigen in gastric juice, improve gastric acid-base environment, and have two-way adjustment effect without toxic side effects.