化学名3,9-二甲氧基-2,10-二羟基原四氢小檗碱左旋千金藤定碱(l-stepholidine,SPD)是从长柄千金藤或河谷地不容中分离得到的白色结晶,是甲氧基被羟基取代的四氢原小檗碱(THPB)的同系物,为多巴胺受体拮抗剂。药理作用镇痛作用小鼠灌胃SPD后对乙酸产生的扭体试验半数有效剂量为223mg/kg。在电刺激小鼠尾根部试验中,60mg/kg SPD的镇痛效果与THPB相当,而小于25 Chemical Name 3,9-dimethoxy-2,10-dihydroxypyrotropin (l-stepholidine, SPD) is incompatible from the long-stem elm vine or valley isolated white Crystallization, a homolog of tetrahydroprotoberberine (THPB) whose methoxy group is replaced by a hydroxyl group, is a dopamine receptor antagonist. Pharmacological analgesic effect The mice writhing after acetic acid generated SPW test half effective dose of 223mg / kg. The analgesic effect of 60 mg / kg SPD was equivalent to that of THPB in electrically stimulated mouse tail roots test and less than 25