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归纳子痫前期的病理生理过程以及可溶性血管内皮生长因子受体-l(sFlt-1)、胎盘生长因子(PLGF)与子痫前期的研究情况,PLGF是血管内皮生长因子(VEGF)家族成员之一,PLGF与Flt-1受体结合时,发挥促血管生成和促绒毛滋养细胞增殖、浸润的效应,而这些生物学功能均可被sFlt-1阻断,且sFlt-1对PLGF具有强效的拮抗作用,调节PLGF的功能。在子痫前期妊娠妇女血清中sFlt-1的水平升高,早于疾病的发生。子痫前期患者血浆中PLGF的水平降低。总结sFlt-1、PLGF预测诊断子痫前期发生及病情严重程度的研究进展,探讨sFlt-1、PLGF在子痫前期临床诊断中的意义。
To summarize the pathophysiological process of preeclampsia and the study of soluble vascular endothelial growth factor-1 (sFlt-1), placental growth factor (PLGF) and preeclampsia, PLGF is a member of the vascular endothelial growth factor (VEGF) family First, when PLGF binds to Flt-1 receptor, it exerts the effect of promoting angiogenesis and promoting villous trophoblast proliferation and infiltration, and these biological functions can be blocked by sFlt-1, and sFlt-1 has a strong effect on PLGF Antagonism, regulate the function of PLGF. The level of sFlt-1 in sera of pre-eclampsia women rises earlier than the onset of the disease. The level of PLGF in the plasma of preeclampsia is reduced. To summarize the research progress of sFlt-1 and PLGF in predicting the occurrence and severity of preeclampsia, and to explore the significance of sFlt-1 and PLGF in the clinical diagnosis of preeclampsia.