糖尿病时,由于胰岛素绝对或相对缺乏,故不仅有糖耐量减低,还有蛋白质的代谢异常。胰岛素对氨基酸代谢的主要作用是促进支链氨基酸(branchedchain amino acid,BCAA)包括缬氨酸(Val)、亮氨酸(Leu)和异亮氨酸(Ile)进入肌肉组织内,合成蛋白质,降低肝脏摄取丙氨酸(alanine)转变成葡萄糖。因此,糖尿病患者有特殊的血浆氨基酸变化。本文分析了34例糖尿病患者和29名正常人血浆9种游离氨基酸,以探讨糖尿病对某些氨基酸代谢的影响。 Diabetes, due to absolute or relative lack of insulin, it is not only impaired glucose tolerance, as well as protein metabolism. The major role of insulin in the metabolism of amino acids is to promote the incorporation of branched chain amino acids (BCAA) including Val, Leu and Ile into muscle tissue, Liver uptake of alanine into glucose. Therefore, patients with diabetes have special plasma amino acid changes. This article analyzes the plasma of 34 patients with diabetes and 29 normal human free amino acids to explore the impact of diabetes on some amino acid metabolism.