论文部分内容阅读
本文报告用长春新碱、柔毛霉素和强的松诱导缓解,用氨甲喋呤+6-巯基嘌呤或单用氨甲喋呤维持缓解的联合用药治疗方案,共治疗急性白血病227例。药物和剂量: 诱导缓解:长春新碱首次1毫克/平方米,以后2毫克/平方米/周;柔毛霉素首次1毫克/平方米,以后2毫克/平方米/周;两种药物同时静脉给药;强的松100毫克/平方米/日,口服。维持缓解:骨髓完全缓解后采用以下方案之一。方案甲: 6-巯基嘌呤(2.5毫克/公斤/日,口服)加氨甲喋呤(15毫克/平方米,每周2次,口服或肌注);方案乙:氨甲喋呤(30毫克/平方米,每周2次,口服或肌注)。
This article reports the use of vincristine, daunorubicin and prednisone induced remission, with methotrexate + 6- mercaptopurine alone or methotrexate alone to maintain the combination of drug treatment regimens, a total of 227 cases of acute leukemia. Drugs and Dosage: Induced Relief: Vincristine for the first time 1 mg / m2, then 2 mg / m2 / week; daunorubicin for the first time 1 mg / m2, then 2 mg / m2 / week; Intravenous administration; prednisone 100 mg / m 2 / day, orally. Maintain remission: Bone marrow after complete remission using one of the following options. Protocol A: 6-mercaptopurine (2.5 mg / kg / day orally) plus methotrexate (15 mg / m2 twice weekly, orally or intramuscularly); Protocol B: methotrexate (30 mg / 2 times, oral or intramuscular).