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目的研究枳壳对丁螺环酮在健康大鼠体内药物动力学的影响。方法将SD大鼠随机分为丁螺环酮组,丁螺环酮加枳壳低剂量组(15 g/kg),丁螺环酮加枳壳高剂量组(30 g/kg),测定给药后5、10、20、30、45、60、90、120、240、360、480、600 min丁螺环酮的血药浓度,计算并比较其药动学参数。结果与丁螺环酮组比较,丁螺环酮加枳壳低剂量组和高剂量组中丁螺环酮AUC(0-t)分别增加2.49和4.18倍,Cmax分别增加1.63和2.57倍,Tmax从0.28 h分别延长至0.52和1.06 h,t1/2从0.96 h分别延长至2.18和4.87 h,差异具有统计学意义(P<0.05)。结论枳壳可增加同服药物丁螺环酮的AUC(0-t)和Cmax,提高丁螺环酮生物利用度,并有剂量依赖性趋势,枳壳与丁螺环酮发生显著的药动学相互作用。
Objective To study the effect of Fructus Aurantii on the pharmacokinetics of Buspirone in healthy rats. Methods SD rats were randomly divided into buspirone group, Buspirone and Citrus aurantium low-dose group (15 g / kg), Buspirone and Citrus aurantium high-dose group (30 g / kg) After drug 5,10,20,30,45,60,90,120,240,360,480,600 min buspirone plasma concentration calculated and compared pharmacokinetic parameters. Results Compared with buspirone group, the AUC (0-t) of buspirone in Buspirone and Fructus Aurantii decreased by 2.49 and 4.18 times, and Cmax increased by 1.63 and 2.57 times, respectively, and Tmax From 0.28 h to 0.52 and 1.06 h respectively, t1 / 2 was prolonged from 0.96 h to 2.18 and 4.87 h, respectively. The difference was statistically significant (P <0.05). Conclusion Fructus Aurantii can increase the AUC (0-t) and Cmax of buspirone and increase the bioavailability of buspirone in a dose-dependent manner. Fructus Aurantii and buspirone have significant pharmacokinetics Learning interaction.