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目的分析2型糖尿病(T2DM)患者维生素D水平及相关影响因素,为干预性研究提供依据。方法采用分层随机抽样方法抽取丽水市10个街道/乡镇270例T2DM患者,开展问卷调查、体格检查及实验室检测。采用高效液相色谱-串联质谱法检测血清25(OH)D3水平,并分析其相关影响因素。结果 270例T2DM患者血清25(OH)D3平均为(22.97±8.07)ng/m L;男性患者25(OH)D3中位数为25 ng/m L,高于女性患者的21 ng/m L(P<0.05);农村患者为23 ng/m L,高于城市患者的20 ng/m L(P<0.05);超重及肥胖的T2DM患者低于BMI正常者(P<0.05)。多元线性回归分析显示,性别、城乡户籍和户外活动时间是维生素D水平的影响因素,β值分别为-5.178、2.369和2.026(P均<0.05)。结论 T2DM患者维生素D水平与性别、城乡户籍、户外活动时间相关,应加强对T2DM患者的维生素D水平监测与户外活动干预。
Objective To analyze the level of vitamin D in patients with type 2 diabetes mellitus (T2DM) and the related influencing factors, so as to provide basis for the intervention study. Methods A stratified random sampling method was used to collect 270 cases of T2DM from 10 streets / towns in Lishui City. The questionnaires, physical examination and laboratory tests were performed. Serum 25 (OH) D3 levels were detected by high performance liquid chromatography-tandem mass spectrometry and the related factors were analyzed. Results The average serum 25 (OH) D3 in 270 T2DM patients was (22.97 ± 8.07) ng / m L and the median 25 (OH) D3 in male patients was 25 ng / m L, which was significantly higher than that of 21 ng / m L (P <0.05). In rural areas, 23 ng / m L was higher than 20 ng / m L in urban patients (P <0.05). Patients with overweight and obese T2DM were lower than those with normal BMI (P <0.05). Multivariate linear regression analysis showed that sex, urban and rural household registration and outdoor activities were the influencing factors of vitamin D levels, with β values of -5.178, 2.369 and 2.026, respectively (all P <0.05). Conclusions The level of vitamin D in T2DM patients is related to gender, urban and rural household registration and time of outdoor activities. The intervention of vitamin D level monitoring and outdoor activities in T2DM patients should be strengthened.