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目的:分析中药归经研究的现状,提出并阐明“穴药”法的中药归经研究法。方法:对中药有效成分群(物)的归经及与经络脏腑功能(象)的互应关系的研究现状进行剖析,找出其不足与解决问题的对策。结果:特定的中药成分群对特定的经络脏腑有选择性的作用,这是中药归经的物质基础,体现“物”性;经络脏腑的功能状态以一定的证候表现出来,体现“象”性,一定功能的经络脏腑对特征中药成分群有反作用,可用于探知和表征经络脏腑,体现“候”性,三者实为“物-象-候”印迹关系。经络脏腑功能状态也可通过针刺特异腧穴改变,而这种改变可以通过中药定量药理学参数表征,据此可建立中药归经研究的“穴药”新方法,也可以探讨中药成分与病证网络靶点的关系,起到一箭双雕的作用。结论:中药与经络脏腑及其功能三者互为“物-象-候”印迹关系,可通过针刺特异性腧穴改变,“穴药”法既是中药归经研究最简捷的方法,也是探知经络脏象重要方法。
OBJECTIVE: To analyze the status quo of TCM research, and to put forward and clarify the Chinese medicine research method of acupuncture medicine. Methods: The research status quo of the relationship between the grouping of the active ingredients of traditional Chinese medicine (TCM) and the reciprocal relationship between the function of the meridian organs and organs was analyzed to find out the shortcomings and countermeasures to solve the problem. Results: The specific Chinese medicine component group has a selective effect on specific meridian organs, which is the material basis of traditional Chinese medicine, which embodies “physical ” properties; the functional state of meridian organs manifests itself with certain syndromes, The “meridian” and certain functions of the meridian organs have a negative effect on the characteristic Chinese medicinal composition, which can be used to detect and characterize the meridians and organs and embody the “waiting” character. The three are actually “object-like-waiting” imprinting relations . The functional status of meridians and organs can also be changed by acupuncture specific acupoints, and this change can be characterized by quantitative pharmacological parameters of traditional Chinese medicine, which can be used to establish a new method of “acupuncture” of traditional Chinese medicine research, can also explore traditional Chinese medicine ingredients and Syndromes network of the relationship between the target, play a double-edged sword. Conclusion: The relationship between the traditional Chinese medicine and the meridian organs and their function are mutually “object-image-wait” imprinting, which can be changed by acupuncture-specific acupoints. The acupuncture-medicine method is not only the simplest method for the study of traditional Chinese medicine , Is also an important method to detect the meridian dirty like.