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目的观察山莨菪碱注射液防治阿奇霉素胃肠道不良反应的效果。方法观察2010年11月至2011年11月在我院儿科应用阿奇霉素治疗呼吸道感染患儿150例,其中80例同时加入山莨菪碱注射液为观察组,另70例不加山莨菪碱注射液为对照组。结果观察组胃肠道不良反应发生率为3.75%,对照组胃肠道不良反应发生率为12.86%,两组比较差异有显著性(χ2=4.21,P<0.05)。对照组轻度不良反应5例,重度不良反应4例,因不良反应停药4例,停药率5.71%;观察组轻度不良反应2例,重度不良反应1例,因不良反应停药1例,停药率1.25%。结论山莨菪碱注射液有较好的防治阿奇霉素滴注过程中胃肠道反应作用,且价廉易购,值得临床推广应用。
Objective To observe the effect of anisodamine injection in preventing and treating side effects of azithromycin in gastrointestinal tract. Methods From November 2010 to November 2011, 150 pediatric patients with respiratory tract infection were treated with azithromycin in our hospital. 80 cases were treated with anisodamin injection as observation group and the other 70 cases were treated with anisodamine injection group. Results The incidence of gastrointestinal adverse reactions was 3.75% in the observation group and 12.86% in the control group. There was significant difference between the two groups (χ2 = 4.21, P <0.05). 5 cases of mild adverse reactions in the control group, 4 cases of serious adverse reactions, 4 cases due to adverse drug withdrawal, withdrawal rate was 5.71%; 2 cases of mild adverse reactions in the observation group, 1 case of serious adverse reactions, withdrawal due to adverse reactions 1 Cases, withdrawal rate 1.25%. Conclusion Anisodamine injection has a good effect on prevention and treatment of gastrointestinal reactions during azithromycin instillation, and is cheap and easy to be purchased. It is worthy of clinical application.