目的：以安乃近、对乙酰氨基酚、双氯灭痛、吲哚美辛、吡罗昔康和普罗帕酮为模型药，进行药物的鼻腔吸收研究，完善和发展鼻腔吸收的系统研究方法。方法：采用Ｖ－Ｃ扩散池进行离体透膜试验；采用大鼠鼻腔循环装置进行在体内吸收试验；鼻腔全身吸收实验在志愿者体内进行，同时还采用示踪元素标记化合物法进行了药物的鼻腔吸收研究。此外，对药物的鼻粘膜纤毛毒性也进行了研究。结果：安乃近、对乙酰氨基酚鼻腔吸收良好，有望开发为鼻腔给药制剂；普罗帕酮鼻纤毛毒性较大，不适合鼻腔给药；另三种药物初步结果表明鼻腔吸收良好，值得进一步研究。结论：本文提出并采用的一系列研究方法适合作药物鼻腔吸收研究 OBJECTIVE: To study the nasal absorption of acetaminophen, diclofenac, indomethacin, piroxicam and propafenone, and to improve and develop the nasal absorption system. Methods: V-C diffusion cell was used for in vitro transmembrane membrane permeation test; rat nasal circulation device was used for in vivo absorption test; systemic nasal absorption test was carried out in volunteers; tracer element labeling compound method Nasal absorption studies. In addition, the nasal mucociliary toxicity of the drug was also studied. Results: Analgin, acetaminophen nasal absorption well, is expected to develop nasal preparations; propafenone nasal cilia toxicity is not suitable for nasal administration; the other three drugs preliminary results show that nasal absorption well, it is worth further the study. Conclusion: A series of research methods proposed and adopted in this paper are suitable for nasal absorption studies