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目的:探讨分析甲状腺激素水平与2型糖尿病(T2DM)的关系。方法:选取2009年3月～2012年3月间我院内分泌门诊收治的2型糖尿病患者99例作为研究对象(所有患者均符合1999年WHO糖尿病诊断和分型标准),根据其病情的轻重程度将其分为轻症组(59例)和重症组(40例),并随机选取同期健康体检者40例作为对照组。应用全自动免疫分析仪对这3组研究对象的甲状腺激素水平(包括FT3值、FT4值、rT3值、TSH值)进行测定和比较,并将比较结果及3组研究对象的临床资料进行回顾性的分析。结果:经统计,轻症组患者的FT3水平明显低于对照组健康体检者,差异显著(P<0.05),具有统计学意义。重症组患者的FT3水平明显低于对照组健康体检者,差异显著(P<0.01),具有统计学意义。这3组研究对象的FT4水平、rT3水平与sTSH水平的差异不显著,不具有统计学意义。结论:甲状腺激素水平的变化与糖尿病的病情进展密切相关。
Objective: To investigate the relationship between thyroid hormone levels and type 2 diabetes mellitus (T2DM). Methods: From March 2009 to March 2012, 99 patients with type 2 diabetes mellitus admitted to our hospital endocrine clinic were enrolled in this study (all patients were in line with the 1999 WHO diagnostic and classification criteria for diabetes), according to the severity of their condition The patients were divided into mild group (59 cases) and severe group (40 cases), and 40 healthy subjects were randomly selected as the control group. Thyroid hormone levels (including FT3 value, FT4 value, rT3 value, TSH value) of these three groups of patients were measured and compared by automatic immunoassay analyzer. The clinical data of the three groups of patients were compared retrospectively Analysis. Results: According to the statistics, FT3 levels in patients with mild disease were significantly lower than those in healthy subjects (P <0.05), which was statistically significant. The level of FT3 in severe group was significantly lower than that in control group (P <0.01), which was statistically significant. There was no significant difference between FT4 level, rT3 level and sTSH level in the three groups of subjects, which was not statistically significant. Conclusion: The change of thyroid hormone level is closely related to the progression of diabetes.