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目的:分析并评价早产儿血清胃泌素浓度检测的应用价值。方法:我院新生儿科自2011年1月至2012年10月期间收治86例早产儿,以43例喂养不耐受的早产儿为观察组,以相同例数即43例无喂养不耐受的早产儿为对照组。分别测定两组患儿在出生后24h内与7d后的血清胃泌素浓度,比较分析两组患儿治疗7d后的临床症状改善状况。结果:与对照组相比,观察组患儿在出生后24h内的血清胃泌素浓度与当日奶量均降低,差异显著(P<0.05);治疗7d后两组患儿的血清胃泌素浓度与当日奶量相比无明显差异(P>0.05)。观察组的恢复至出生体重时间及达全量肠内营养时间明显延长,差异显著(P<0.05或P<0.01);两组患儿住院期间血清总胆红素浓度高峰值及血清前白蛋白浓度相比无明显差异(P>0.05)。全部患儿未见坏死性小肠结肠炎及吸入性肺炎等重症喂养并发症病例。结论:早产儿血清胃泌素浓度能够反映出胃肠功能紊乱状况,采取微量喂养有利于早产儿胃肠道发育成熟。
Objective: To analyze and evaluate the value of serum gastrin in preterm infants. Methods: Neonatology in our hospital from January 2011 to October 2012 86 cases of preterm children admitted to 43 cases of intolerant premature children as the observation group, with the same number of 43 cases were fed intolerant Preterm children as control group. The levels of serum gastrin in the two groups were measured respectively within 24 hours and 7 days after birth. The clinical symptoms of the two groups were compared after treatment for 7 days. Results: Compared with the control group, the levels of serum gastrin in the observation group within 24 hours after birth were lower than those in the control group (P <0.05). Serum gastrin There was no significant difference between the concentration and the milk amount on the same day (P> 0.05). The time from recovery to birth weight and the total enteral nutrition time in the observation group were significantly longer (P <0.05 or P <0.01). The peak serum total bilirubin concentration and pre-serum albumin concentration No significant difference (P> 0.05). All children with necrotizing enterocolitis and aspiration pneumonia and other severe feeding complications. Conclusion: Serum gastrin concentration in preterm infants can reflect the status of gastrointestinal disorders. Taking micro-feeding is beneficial to the development of gastrointestinal tract in premature infants.