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目的分析青海省三江源地区布鲁氏菌病血清检测结果,描述该地区人群血清抗体在职业、年龄、性别、民族等方面的差异。方法对三江源地区的九县一镇范围内的人群进行随机抽样调查,按《全国人间布病监测方案(试行)》中的要求开展流行病学调查,采集血清,用虎红凝集试验(RBPT)、试管凝聚试验(SAT)、抗人球蛋白试验(Coomb’s)、补体结合试验(CFT)、酶联免疫吸附试验(ELISA)检测抗体水平。结果检测6 310人份,RBPT阳性141人份,SAT阳性25人份,CFT阳性28份,SAT阴性、CFT阳性的有15份。血清流行病学调查显示,不同地区间差异有统计学意义(χ2=23.614,P<0.05),在141例感染者中,年龄最小的10岁,最大的74岁,不同年龄段间差异无统计学意义(χ2=10.192,P>0.05)男女感染比例为1∶1.2,经检验男女差异无统计学意义(χ2=0.96,P>0.05);藏族占82.27%,蒙族占13.48%,汉族占2.84%,回族占0.71%,撒拉族占0.71%。结论布病流行强度有增强趋势应加大布病监测力度,开展人畜防治合作,综合评价流行风险因素,为布病防治提供科学依据。
Objective To analyze the serum test results of brucellosis in Sanjiangyuan area of Qinghai Province, and to describe the differences of occupational, age, sex and ethnicity of the serum antibodies among the population in this area. Methods A random sampling survey was conducted on the population in the nine counties and one town in the Three Rivers Region. The epidemiological survey was conducted according to the requirements in the “National Human Burden Surveillance Program (for Trial Implementation)”. Serum was collected and analyzed by the Tiger Red Agglutination Test (RBPT) ), SAT, Coomb’s, CFT and ELISA. Results A total of 6 310 individuals with RBPT positive, 141 positive, SAT positive 25, CFT positive 28, SAT negative and 15 CFT positive were detected. Serological epidemiological survey showed that there were significant differences among different regions (χ2 = 23.614, P <0.05). Among the 141 infected persons, the youngest 10 years old and the oldest 74 years old, there was no statistical difference among different age groups There was no significant difference between men and women (χ2 = 0.96, P> 0.05). The percentage of Tibetans was 82.27%, that of Mongols was 13.48%, Han was 2.84 %, Hui 0.71%, Salar 0.71%. Conclusion Streptococcal disease epidemic intensity should be strengthened. Closure surveillance should be intensified to prevent and control human and livestock diseases. Comprehensive evaluation of epidemic risk factors should provide a scientific basis for the prevention and treatment of brucellosis.