原发性巨球蛋白血症 (PMG)是 B淋巴细胞恶性增生性疾病。随着我国老龄化社会的到来 ,此种疾病的发病率亦有明显增加。当前治疗仍以化疗为主 ,但对血清中高水平的 Ig M的下降较缓慢 ,疗效不满意。本文对单用化疗无效的 6例 PMG患者采用血浆置换 (PE)联合化疗治疗取得了明显的疗 Primary macroglobulinemia (PMG) is a malignant proliferative disorder of B lymphocytes. With the advent of an aging society in China, the incidence of this disease has also increased significantly. The current treatment is still based on chemotherapy, but the decline in high levels of IgM in serum is slow and the efficacy is not satisfactory. In this article, 6 patients with PMG who were not responding to chemotherapy alone were treated with plasma exchange (PE) combined with chemotherapy.