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目的 观察服用复方降压片2年的1或2级原发性高血压患者的降压效果及该药对血糖、胰岛素、尿酸、血脂水平的影响。方法 复方降压片以小剂量开始逐渐加量至血压稳定24周后,再逐渐减药,最终以最小的剂量、最少服药次数保持稳定的正常血压;在治疗前后进行血糖、胰岛素、血钾、总胆固醇、甘油三酯、尿酸等检测。结果 98例轻中度高血压病患者2年血压控制有效率为74 .5% (73 /98),服药次数每日1次者48例(49% ),每日2次者33例(33. 7% ),每日3次者17例(17. 3% );治疗前后血糖、胰岛素、血钾、总胆固醇、甘油三酯、尿酸等无明显变化(P>0. 05),患者无心脑血管并发症发生。结论 复方降压片长期应用降压效果良好,半数病例每日1次服药可获得满意的降压效果,不良反应少。
Objective To observe the effect of antihypertensive effect of blood pressure, insulin, uric acid and blood lipid in patients with essential hypertension of grade 1 or 2 taking compound antihypertensive tablets for 2 years. Methods The compound antihypertensive tablets began to gradually increase in small dose until the blood pressure stabilized for 24 weeks, and then gradually reduce the dose, and finally to the minimum dose, the minimum number of doses to maintain a stable normal blood pressure; before and after treatment, blood glucose, insulin, serum potassium, Total cholesterol, triglycerides, uric acid and other tests. Results The effective rate of two-year blood pressure control was 74.5% (73/98) in 98 patients with mild-to-moderate hypertension. 48 patients (49%) took medication once daily and 33 patients (33 .7%) and 17 cases (17.3%) three times a day. There was no significant change in blood glucose, insulin, serum potassium, total cholesterol, triglyceride and uric acid before and after treatment (P> 0.05) Cardiovascular and cerebrovascular complications occur. Conclusions The antihypertensive effect of compound antihypertensive tablets is good for a long time. Half of the patients can get satisfactory antihypertensive effect once a day, with less adverse reactions.