急性白血病(AL)的诊断和分类依靠包括细胞形态学、免疫表型、细胞遗传学及分子生物学等多方面指标。大多数AL可通过这些方式明确地分为髓系、B或T淋巴系~([1])。然而,部分AL细胞缺乏向单一造血系列分化的特征,包括缺乏特异性抗原、表达两类或两类以上抗原。混合表型急性白血病(mixed phenotype acute leukemia,MPAL)就是其中的一类。MPAL较少见,发病占所有AL的2%~5%~([2-4])。历 The diagnosis and classification of acute leukemia (AL) rely on a variety of indicators including cellular morphology, immunophenotyping, cytogenetics and molecular biology. Most of the AL by these means can be clearly divided into myeloid, B or T lymphatic system ~ ([1]). However, some AL cells lack the features that differentiate into a single hematopoietic lineage, including the lack of specific antigens, and the expression of two or more antigens. Mixed phenotype acute leukemia (MPAL) is one of them. MPAL is rare, the incidence of all AL 2% ~ 5% ~ ([2-4]). calendar