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目的初步探讨住院患者高PTH血症检出情况。方法调取2014年8月至2016年8月在新疆维吾尔自治区人民医院住院的患者1123例纳入本研究,年龄15~83岁,其中汉族612例[男/女:267/345,平均年龄(50.9±14.2)岁],维吾尔族511例[男/女:244/267,平均年龄(52.4±13.4)岁],采用化学发光法检测血清甲状旁腺激素(PTH)、25-羟维生素D[25(OH)D],检测血钙(Ca)、血磷(P)、血镁(Mg)、白蛋白、肌酐(Cr)、碱性磷酸酶(ALP)水平,按照血清25(OH)D水平分为维生素D缺乏组(<20 ng/mL)、不足组(≤20<30 ng/mL)和充足组(≥30 ng/mL);根据PTH水平分为<65pg/mL组,≥65 pg/mL组,并对维汉两民族间代谢指标进行比较。结果维吾尔族高PTH血症(≥65 pg/mL组)检出率高于汉族(维/汉:18.79%vs 14.05%,χ2=4.596,P=0.032),女性高于男性(男/女:17.03%vs 18.55%,χ2=0.463,P=0.496)。维吾尔族维生素D充足、不足、缺乏分别为2.94%、5.09%、91.98%,汉族分别为4.08%、9.48%、86.44%,维吾尔族25(OH)D缺乏的检出率明显高于汉族(χ2=8.697,P=0.003)。在维生素D缺乏组,高PTH血症检出率明显升高,且维吾尔族高于汉族;偏相关分析提示血清PTH水平与25(OH)D呈负相关(P=0.002),与P、Mg呈正相关(P<0.001)。结论维汉两民族患者血清PTH水平无统计学差异,住院患者普遍存在维生素D缺乏,维吾尔族尤为严重;住院患者高PTH血症检出率存在民族差异可能原因是维生素D缺乏。
Objective To investigate the detection of high PTH inpatients. Methods A total of 1123 inpatients admitted to the People’s Hospital of Xinjiang Uyghur Autonomous Region from August 2014 to August 2016 were enrolled in this study. The age ranged from 15 to 83 years. Among them, 612 Han [female / male: 267/345, mean age (50.9) ± 14.2) years old, and 511 Uygur women [male / female: 244/267 with an average age of (52.4 ± 13.4) years]. Serum parathyroid hormone (PTH), 25-hydroxyvitamin D (OH) D]. Serum calcium (Ca), phosphorus (P), magnesium (Mg), albumin, creatinine (Cr) and alkaline phosphatase (ALP) Divided into vitamin D deficiency group (<20 ng / mL), deficient group (≤20 <30 ng / mL) and adequate group (≥30 ng / mL) / mL group, and to compare the metabolic indicators between the two ethnic groups in Uygur and Han. Results The detection rate of Uygur high PTH hyperlipidemia (≥ 65 pg / mL group) was higher than that of Han nationality (Uygur / Han: 18.79% vs 14.05%, χ2 = 4.596, P = 0.032) 17.03% vs 18.55%, χ2 = 0.463, P = 0.496). The prevalence of vitamin D deficiency was 2.94%, 5.09% and 91.98% in Uygur nationality and 4.08%, 9.48% and 86.44% in Han nationality respectively. The detection rate of Uygur 25 (OH) D deficiency was significantly higher than that of Han nationality (χ2 = 8.697, P = 0.003). In the group of vitamin D deficiency, the detection rate of hyperphosphatemia increased significantly, and the Uygur was higher than that of Han nationality. Partial correlation analysis indicated that serum PTH level was negatively correlated with 25 (OH) D (P = 0.002) (P <0.001). Conclusions There is no significant difference in serum PTH levels between the two ethnic groups in Uyghur and Han ethnicity. The prevalence of vitamin D deficiency in hospitalized patients is especially high in Uygur nationality. There may be ethnic differences in the prevalence of high PTH inpatients due to vitamin D deficiency.