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目的探讨经动脉化疗栓塞治疗晚期卵巢癌的疗效。资料与方法对48例晚期卵巢癌患者行髂内动脉、卵巢动脉化疗栓塞,其中Ⅲ期26例、Ⅳ期22例,灌注药物剂量分别为:顺铂(DDP)50mg/m2或卡铂400～600mg、丝裂霉素(MMC)6～10mg。栓塞剂选用明胶海绵。在介入术前3h静脉注射5-氟尿嘧啶(5-FU)1000～1250mg。结果采用单纯介入治疗者总有效率69.2%(9/13),完全缓解(CR)4例,部分缓解(PR)5例,稳定(SD)3例,进展(PD)1例,患者2年生存率46.2%(6/13)。采用介入+手术治疗者总有效率91.4%(32/35),CR21例,PR11例,SD3例,患者2年生存率71.4%(25/35)。无严重并发症发生。结论经导管动脉化疗栓塞治疗晚期卵巢癌疗效肯定,为综合治疗晚期卵巢癌增加了新的治疗手段,并为无法手术者提供了二期手术机会。
Objective To investigate the efficacy of transcatheter arterial chemoembolization in the treatment of advanced ovarian cancer. Materials and Methods 48 cases of advanced ovarian cancer patients underwent internal iliac artery and ovarian artery chemoembolization, including 26 cases in stage Ⅲ and 22 cases in stage Ⅳ. The doses of perfusion were 50 mg / m2 of cisplatin (DDP) 600mg, mitomycin (MMC) 6 ~ 10mg. Embolization agent selection gelatin sponge. 3h before intervention, intravenous injection of 5-fluorouracil (5-FU) 1000 ~ 1250mg. Results The total effective rate was 69.2% (9/13), complete remission (CR) 4 cases, partial remission (PR) 5 cases, stable (SD) 3 cases, progression (PD) 1 case and patients 2 years Survival rate was 46.2% (6/13). The total effective rate was 91.4% (32/35). There were 21 CR cases, 11 PR cases and 3 SD cases. The 2-year survival rate was 71.4% (25/35). No serious complications occurred. Conclusions Transcatheter arterial chemoembolization in the treatment of advanced ovarian cancer has a definite effect and provides new treatment for the comprehensive treatment of advanced ovarian cancer. It also provides the second-stage surgery opportunity for those who can not operate.