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为探讨类风湿关节炎(rheumatoid arthritis,RA)伴发心血管疾病(cardiovascular disease,CVD)的风险指标,收集在台州医院内分泌科、心血管内科住院的147例患者的临床资料及实验室记录,并将所有患者分为RA伴发CVD组(A组)、RA组(B组)、CVD组(C组)三组。回顾性分析RA伴发CVD的相关风险指标。同时选取50例健康对照组为D组作比较。结果显示:四组研究对象的血液检测指标显示RA伴发CVD组、单纯RA组的红细胞沉降率(erythrocyte sedimentation rate,ESR)、C-反应蛋白(C-reactive protein,CRP)炎症指标高于CVD组和健康对照组(P<0.05),RA伴发CVD组的尿酸(UA)、D-二聚体等水平明显高于其他三组(P<0.05)。相关性结果显示CRP与脂蛋白(a)[LP(a)],ESR、类风湿因子(RF)与D-二聚体呈正相关。回归分析结果显示高血糖、D-二聚体、LP(a)、UA是RA伴发CVD的危险因素。对RA患者早期进行全面的体格检查及相关危险指标如D-二聚体、LP(a)等的检测,可降低RA伴发CVD的风险。
To investigate the risk of rheumatoid arthritis (RA) associated with cardiovascular disease (CVD), the clinical data and laboratory records of 147 patients hospitalized in Department of Endocrinology and Cardiology of Taizhou Hospital were collected. All patients were divided into three groups: RA-associated CVD group (group A), RA group (group B) and CVD group (group C). Retrospective analysis of risk factors associated with RA with CVD. At the same time select 50 healthy control group for the D group for comparison. The results showed that the indexes of blood test in the four groups of subjects showed that erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) index of inflammation in RA-associated CVD group and RA-only group were higher than those in CVD group (P <0.05). The levels of uric acid (UA) and D-dimer in RA-associated CVD group were significantly higher than those in the other three groups (P <0.05). Correlation results showed that CRP was positively correlated with lipoprotein (a) [LP (a)], ESR, rheumatoid factor (RF) and D-dimer. Regression analysis showed that hyperglycemia, D-dimer, LP (a) and UA were risk factors of RA with CVD. Early comprehensive physical examination of RA patients and related risk indicators such as D-dimer, LP (a), etc., can reduce the risk of RA with CVD.