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目的:探讨定量检测24 h尿液样本N-乙酰-β-D-氨基葡萄糖苷酶(UNAG)以及其与肌酐(UCr)比值在IgA肾病(IgAN)早期肾损害方面的应用价值。方法:收集57例IgAN患者,根据随机尿蛋白定性检测,分为尿蛋白定性阴性组与尿蛋白定性阳性组;利用Olympus AU5400自动生化分析仪,检测57例IgAN患者及30例健康对照组的24 h尿微量总蛋白(UmTP)、UNAG与UCr的含量,并计算出UmTP/Cr与UNAG/Cr;利用SPSS17.0对3组的UmTP、UNAG、UmTP/Cr及UNAG/Cr进行统计性分析。结果:IgAN尿蛋白定性阴性组UmTP及UmTP/Cr与健康对照组数据相差不大,差异无统计学意义(P>0.05);IgAN尿蛋白定性阴性组UNAG及UNAG/Cr明显高于健康对照组,差异有统计学意义(P<0.01);IgAN尿蛋白定性阳性组UmTP、UNAG、UmTP/Cr及UNAG/Cr明显高于阴性组及健康对照组,差异有统计学意义(均P<0.01)。结论:24hUNAG及UNAG/Cr可作为IgAN早期肾损伤较敏感的指标。
Objective: To investigate the value of quantitative detection of UNAG in 24 h urinary samples and the ratio of creatinine to creatinine (UCr) in early renal damage of IgA nephropathy (IgAN). Methods: Fifty-seven patients with IgAN were collected and randomly divided into urinary protein negative group and urine protein positive group according to the qualitative detection of random urinary protein. Using Olympus AU5400 automatic biochemical analyzer, 57 patients with IgAN and 30 healthy controls were detected 24 U urinary total protein (UmTP), UNAG and UCr contents were calculated and UmTP / Cr and UNAG / Cr were calculated. UmTP, UNAG, UmTP / Cr and UNAG / Cr of three groups were calculated by SPSS17.0. Results: The positive rates of UNATP and UNAG / Cr in IgAN protein negative group were not significantly different from those in healthy control group (P> 0.05). The positive rates of UNAG and UNAG / Cr in IgAN protein negative group were significantly higher than those in healthy control group (P <0.01). The positive rates of UmTP, UNAG, UmTP / Cr and UNAG / Cr in IgAN protein positive group were significantly higher than those in negative group and healthy control group (all P <0.01) . Conclusion: 24hUNAG and UNAG / Cr can be used as indicators of IgAN early renal injury more sensitive.