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目的评估N末端脑钠肽前体(NT-pro BNP)对急性冠状动脉综合征(ACS)患者冠状动脉病变严重程度及短期预后的临床价值。方法 216例ACS患者均进行心电图、超声心动图检查,并测定其肌钙蛋白I、血肌酐、C-反应蛋白和NT-pro BNP水平。根据NT-pro BNP水平将患者分为2组:NT-pro BNP<300pg/ml的88例患者划为A组,NT-pro BNP水平≥300pg/ml的128例患者划为B组。结果 B组患者的射血分数显著低于A组患者,冠脉多支病变的比例、Gensini积分显著高于A组患者,而A组患者的TIMI血流评分明显高于B组患者,差异均有统计学意义(P<0.05)。B组患者住院期间心力衰竭的发生率及住院天数均大于A组患者(P<0.05)。结论 NT-pro BNP对急性冠脉综合征患者冠状动脉病变的严重程度及短期预后有一定有预测价值。
Objective To evaluate the clinical value of NT-pro BNP in the severity of coronary lesions and short-term prognosis in patients with acute coronary syndrome (ACS). Methods Totally 216 ACS patients were examined by electrocardiogram and echocardiography, and the levels of troponin I, serum creatinine, C-reactive protein and NT-pro BNP were measured. The patients were divided into two groups according to the level of NT-pro BNP: 88 patients with NT-pro BNP <300 pg / ml were classified as group A and 128 patients with NT-pro BNP level> 300 pg / ml were classified as group B. Results The ejection fraction of patients in group B was significantly lower than that of patients in group A, the ratio of coronary multivessel disease and Gensini score was significantly higher than that of patients in group A. The TIMI flow score in group A was significantly higher than that in patients in group B There was statistical significance (P <0.05). The incidence of hospital-acquired heart failure and hospital stay in group B were significantly greater than those in group A (P <0.05). Conclusion NT-pro BNP may have some predictive value for the severity of coronary artery disease and short-term prognosis in patients with acute coronary syndrome.