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随着人类社会对健康需求的日益提高和科学认知水平的不断深入,中药的合理应用以及安全性和有效性问题受到社会的广泛关注。随着以“十八反”为代表的中药配伍禁忌研究逐渐深入,对中药配伍禁忌物质基础的认知达到新的水平。本文基于中医配伍理论体系中的代表性禁忌配伍药组为研究对象,通过构建毒效生物学评价相关联、配伍毒性效应物质相兼顾、体外-体内药物相互作用评价相结合和药味配伍-成分协同分层次递进研究等中药配伍禁忌复杂毒效物质相互作用的适宜研究方法和技术体系,形成了以反药组合-毒效物质-量毒效关系-体内外转化与代谢特征相互关联的中药配伍禁忌复杂毒效物质研究思路,为中药配伍禁忌现代研究提供了有益的参考和借鉴。
With the increasing demand for health and the deepening of scientific cognition in human society, the rational application of traditional Chinese medicine and the problems of safety and efficacy have drawn widespread public attention. With the study on contraindications of compatibility of traditional Chinese medicines represented by “eighteen anti”, the cognition of the material basis of compatibility of contraindications to traditional Chinese medicine has reached a new level. In this paper, based on the representative compatibility taboos of traditional Chinese medicine (TCM) compatibility system, the study was established by constructing the biological evaluation of toxicological effects, taking into account the compatibility of toxic effects, the evaluation of drug-drug interaction in vitro and in vivo, Level progressive research and other traditional Chinese medicine compatibility and taboo complex toxic substances interaction of appropriate research methods and technical system, formed a combination of anti-drug - toxic substances - the amount of toxic and toxic effect - in vitro and in vitro transformation and metabolic characteristics of interrelated traditional Chinese medicine compatibility Taboo complex toxicological substances research ideas for the compatibility of traditional Chinese medicine taboo modern research provides a useful reference and reference.