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目的:探讨安息香与冰片配伍对安息香主要成分苯甲酸、肉桂酸药代动力学的影响。方法:SD大鼠随机分为两组,分别灌胃给予单味安息香及安息香-冰片配伍药液,采集不同时间点的血浆样品,分别测定血浆中苯甲酸及肉桂酸的含量,并计算其药代动力学参数。结果:给予单味安息香和安息香-冰片配伍药液的Tmax分别为苯甲酸(1.57±1.99),(11.42±3.78)min,肉桂酸(32.86±3.13),(11.71±2.96)min;Cmax分别为苯甲酸(34.93±11.65),(40.35±22.72)mg·L-1,肉桂酸(2.96±1.10),(3.43±1.38)mg·L-1;AUC(0~∞)分别为苯甲酸(4 481.42±879.21),(3 942.21±977.52)min·μg-1·mL-1,肉桂酸(601.16±45.84),(401.33±23.35)min·μg-1·mL-1。结论:安息香与冰片配伍,苯甲酸和肉桂酸的Tmax显著减小,提示二药配伍能加快苯甲酸和肉桂酸在大鼠体内的吸收速度。
Objective: To investigate the effects of compatibility of benzoin and borneol on the pharmacokinetics of benzoic acid and cinnamic acid, the main components of benzoin. Methods: SD rats were randomly divided into two groups, respectively, given a single flavor benzoin and benzoin - borneol compatibility liquid samples collected at different time points, were measured in plasma levels of benzoic acid and cinnamic acid, and calculate the drug Generational dynamics parameters. Results: The Tmax of benzoic acid (1.57 ± 1.99), (11.42 ± 3.78) min, and cinnamic acid (32.86 ± 3.13) and (11.71 ± 2.96) min, respectively, for single benzoin and benzoin- Benzoic acid (34.93 ± 11.65), (40.35 ± 22.72) mg · L-1, cinnamic acid (2.96 ± 1.10) and (3.43 ± 1.38) mg · L- 481.42 ± 879.21), (3942.21 ± 977.52) min · μg-1 · mL-1, and cinnamic acid (601.16 ± 45.84), (401.33 ± 23.35) min · μg-1 · mL-1. Conclusion: Comparing benzoine with borneol, the Tmax of benzoic acid and cinnamic acid decreased significantly, suggesting that the combination of two drugs can speed up the absorption rate of benzoic acid and cinnamic acid in rats.