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目的:探讨小细胞肺癌组织中突变型P53与Bcl-2的表达对生存期的影响。方法:用SP免疫组化法检测40例小细胞肺癌组织中突变型P53与Bcl-2蛋白的表达情况,并将生存期进行相关分析。结果:小细胞肺癌组织中突变型P53与Bcl-2蛋白的阳性表达率明显高于正常肺组织(P<0.05)。突变型P53或Bcl-2蛋白阳性表达组生存期明显低于阴性表达组(P<0.05)。结论:突变型P53与Bcl-2蛋白阳性表达均与小细胞肺癌的预后有关。
Objective: To investigate the effect of the expression of mutant P53 and Bcl-2 on the survival in small cell lung cancer. Methods: The expression of mutant p53 and Bcl-2 protein in 40 cases of small cell lung cancer was detected by SP immunohistochemical method, and the correlation of survival time was analyzed. Results: The positive rate of mutant P53 and Bcl-2 protein in small cell lung cancer was significantly higher than that in normal lung tissue (P <0.05). Survival of mutant P53 or Bcl-2 protein positive group was significantly lower than that of negative group (P <0.05). Conclusion: The positive expression of mutant p53 and Bcl-2 protein are both related to the prognosis of SCLC.