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采用S-P免疫组化方法对36例口腔颌面部上皮性恶性肿瘤进行表皮生长因子受体(epidermalgrowthfactorreceptor,EGFR)检测。结果发现,EGFR在口腔颌面部上皮性恶性肿瘤中的阳性率为69.5%。具有浸润性、分化程度差、恶性程度高及伴有淋巴结转移的肿瘤,EGFR呈阳性表达。研究提示,EGFR阳性表达与口腔颌面上皮性恶性肿瘤的发生有一定的关系,并可作为预测肿瘤患者预后的一个指标
Epidermal growth factor receptor (EGFR) was detected in 36 cases of oral and maxillofacial epithelial malignant tumors by S-P immunohistochemistry. The results showed that the positive rate of EGFR in oral and maxillofacial epithelial malignancies was 69.5%. Tumors with invasiveness, poor differentiation, high degree of malignancy, and lymph node metastasis were positive for EGFR expression. Research suggests that the positive expression of EGFR has a certain relationship with the occurrence of oral and maxillofacial malignancies, and can be used as an indicator to predict the prognosis of cancer patients.