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目的探讨胸液腺苷脱氨酶、溶菌酶、γ-干扰素的检测对诊断结核性胸膜炎的价值。方法采用酶显色法和酶联免疫吸附法分别对结核性和癌性胸腔积液腺苷脱氨酶、溶菌酶、γ-干扰素进行测定。结果腺苷脱氨酶:结核性胸膜炎组(43.92±12.25)U/L,癌性胸膜炎组(8.69±6.92)U/L,二者有统计学差异(P<0.01);溶菌酶:结核性胸膜炎组(59.1±14.1)μg/ml,恶性胸膜炎组(16.2±8.1)μg/ml,二者有统计学差异(P<0.01);γ-干扰素:结核性胸膜炎组(520.29±82.48)pg/ml,癌性胸膜炎组(49.67±30.32)pg/ml,二者之间有统计学差异(P<0.01)。结论腺苷脱氨酶、溶菌酶、γ-干扰素的检测对结核性胸膜炎的诊断具有重要的临床意义。
Objective To investigate the diagnostic value of pleural fluid adenosine deaminase, lysozyme and γ-interferon in the diagnosis of tuberculous pleurisy. Methods The chromogenic and enzymatic pleural effusion of adenosine deaminase, lysozyme and γ-interferon were determined by enzymatic chromogenic assay and enzyme-linked immunosorbent assay respectively. Results The levels of adenosine deaminase in tuberculous pleurisy group (43.92 ± 12.25) U / L and cancerous pleurisy group (8.69 ± 6.92) U / L were significantly different (P <0.01); lysozyme: tuberculous (59.1 ± 14.1) μg / ml in pleuritis group and 16.2 ± 8.1 μg / ml in malignant pleurisy group (P <0.01), while IFN-γ in tuberculous pleurisy group (520.29 ± 82.48) pg / ml, and pleural effusion group (49.67 ± 30.32) pg / ml, with statistical significance (P <0.01). Conclusion The detection of adenosine deaminase, lysozyme and γ-interferon has important clinical significance for the diagnosis of tuberculous pleurisy.