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[目的]探讨硝普钠联合多巴胺治疗难治性心衰患者的疗效及对实验室常规指标、肾功能的影响.[方法]92例难治性心衰患者,随机分为两组,各46例:对照组给予常规治疗,观察组在此基础上给予硝普钠和多巴胺治疗.比较两组疗效,治疗前后心率(HR)、平均动脉压(MAP)、呼吸频率(RR);比较心功能指标左室射血分数(LVEF)、心胸比值(CTR)及 N 端脑钠肽前体(NT-proBNP)以及两组6min 步行实验(6MWT)、血清肌酐(SCr)、血尿素氮(BUN)、血尿酸(UA)水平,同时观察不良反应.[结果]观察组治疗有效率为95.65%(44/46)明显高于对照组的80.43%(37/46)(P<0.05);治疗后观察组 HR、MAP 及 RR均低于对照组(P<0.05);LVEF高于对照组,CTR、NT-proBNP 水平低于对照组(P<0.05);治疗后观察组6MWT 高于对照组(P<0.05),而其SCr、BUNL、UA较对照组明显降低(P0.05).[结论]硝普钠联合多巴胺可有效改善难治性心衰患者实验室常规指标,保护其肾功能,且不良反应少,值得在临床推广应用.“,”[Objective]To investigate the protective effects of sodium nitroprusside combined with dopamine on the routine laboratory indexes and renal function in patients with refractory heart failure.[Methods]A total of 92 patients with refractory heart failure were randomly divided into two groups,with 46 cases in each group.Pa-tients in the control group received conventional treatment,while patients in the observation group were treated with sodium nitroprusside and dopamine in addition to routine treatment.The total effective rate was compared be-tween the two groups.The heart rate (HR),mean arterial pressure (MAP),respiratory rate(RR),left ventricu-lar ej ection fraction (LVEF),cardiothoracic ratio (CTR),N-terminal pro-brain natriuretic peptide (NT-proB-NP),and 6min walk test(6MWT)were used to evaluate the cardiac function.Serum creatinine(SCr),blood urea nitrogen (BUN)and blood uric acid(UA)were renal function indicators.Adverse reactions were also recorded and compared between the two groups.[Results]The effective rate in the observation group,95.65% (44/46),was significantly higher than that in the control group,80.43% (37/46)(P <0.05).After treatment,HR,MAP, and respiratory rate in the observation group were lower than those in the control group (P <0.05).Meanwhile CTR and NT-proBNP levels in the observation group were lower than those in control group (P <0.05).On the other hand,LVEF and 6MWT in the observation group were superior to those in the control group (P <0.05), while SCr,BUN and UA levels were significantly lower(P 0.05).[Conclusion]Sodium nitro-prusside combined with dopamine can effectively improve the routine laboratory indexes and protect the renal func-tion in the treatment of patients with refractory heart failure and is worthy of clinical application.