目的:了解前列腺液的微生物感染情况及对临床常用药物的耐药性。方法:对5000例门诊慢性前列腺炎患者的前列腺液进行细菌培养和药敏试验,同时检测解脲支原体、人型支原体和沙眼衣原体。结果:5000例前列腺液标本中微生物感染800例(16.0%),其中,支原体和衣原体阳性505例,细菌培养阳性295例。药敏显示:解脲支原体(Uu)对环丙沙星耐药率为96.0%,可乐必妥耐药率为89.2%,司帕沙星耐药率为87.6%。凝固酶阴性葡萄球菌(CONS)对阿奇霉素耐药率为84.0%,对青霉素耐药率为93.4%。大肠埃希氏菌对环丙沙星耐药率为67.8%,氨苄青霉素耐药率为87.2%。淋病奈瑟氏菌对环丙沙星耐药率为83.3%,可乐必妥耐药率为89.7%,青霉素耐药率为88.1%。结论:本组病例显示前列腺液微生物分布复杂,以支原体、衣原体感染为主,细菌感染仍不可忽略。药敏结果显示:常见几种微生物对喹诺酮类耐药率均高,临床应根据实验室检测结果予以准确诊断。 Objective: To understand the microbial infection of prostatic fluid and clinical drug resistance. Methods: Bacterial culture and drug sensitivity test were performed on prostatic fluid in 5000 outpatients with chronic prostatitis. Meanwhile, Ureaplasma urealyticum, Mycoplasma hominis and Chlamydia trachomatis were detected. Results: Among the 5000 prostatic fluid specimens, 800 (16.0%) were infected with microorganisms. Among them, 505 were positive for mycoplasma and chlamydia, and 295 were positive for bacterial culture. Drug susceptibility showed that the drug resistance rates of Uu to ciprofloxacin were 96.0%, 89.2% and sparfloxacin were 87.6%. Coagulase-negative staphylococci (CONS) on azithromycin resistance was 84.0%, resistance to penicillin 93.4%. Escherichia coli ciprofloxacin resistance rate was 67.8%, ampicillin resistance rate was 87.2%. The Neisseria gonorrhoeae resistance rate to ciprofloxacin was 83.3%, the rate of cocaffeine was 89.7%, and the rate of penicillin resistance was 88.1%. Conclusion: The group of patients showed that the distribution of prostatic fluid micro-organisms to Mycoplasma, chlamydia-based infection, bacterial infection can not be ignored. Susceptibility results show that: a few common micro-organisms quinolone resistance rates are high, clinical should be based on laboratory test results to be accurately diagnosed.