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目的观察丹参多酚酸辅治伴高同型半胱氨酸血症脑梗死的疗效。方法选取2013年6月-2014年12月医院收治的伴高同型半胱氨酸血症脑梗死患者75例。随机分为A、B、C 3组各25例。A组常规治疗组、B组常规治疗基础上给予叶酸和甲钴胺口服、C组常规治疗基础上给予注射用丹参多酚酸治疗,治疗2周并观察3组的同型半胱氨酸变化。结果 A组治疗后血清同型半胱氨酸较治疗前比较差异无统计学意义(P>0.05);B组和C组的治疗后血清同型半胱氨酸水平较治疗前均明显下降,差异有统计学意义(P<0.01)。B组、C组治疗后与A组比较血清同型半胱氨酸比较差异有统计学意义(P<0.05);B组与C组干预后血清同型半胱氨酸比较差异无统计学意义(P>0.05)。结论丹参多酚酸辅治伴高同型半胱氨酸血症脑梗死的疗效满意,对患者神经功能恢复有利。
Objective To observe the curative effect of salvia miltiorrhiza polyphenols supplementation on cerebral infarction with hyperhomocysteinemia. Methods Seventy-five patients with hyperhomocysteinemia and cerebral infarction admitted from June 2013 to December 2014 in our hospital were enrolled. Randomly divided into A, B, C 3 group of 25 cases. A group of conventional treatment group, B group on the basis of conventional treatment folic acid and mecobalamin given orally, C group on the basis of conventional treatment was given Salvia polyphenols injection for 2 weeks and observed changes in the three groups of homocysteine. Results There was no significant difference in serum homocysteine level between the two groups after treatment (P> 0.05). The levels of plasma homocysteine in group B and group C after treatment were significantly lower than those before treatment Statistical significance (P <0.01). Serum homocysteine levels in group B and group C were significantly different from those in group A (P <0.05); there was no significant difference in serum homocysteine between group B and C (P > 0.05). Conclusion Salvia polyphenols supplementation with high homocysteinemia cerebral infarction with satisfactory results, the recovery of nerve function in patients with favorable.