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肾上腺皮质类固醇对炎症反应具有强烈的抑制作用。由于类固醇可保持血管内皮层的完整、防止血管渗透性增加,可减少向组织内渗出;保持细胞膜完整和溶酶体膜完整,防止其被破坏后释放酸性水解酵素酶;并抑制受损组织内可进一步破坏组织的吞噬作用,故对炎症、变态反应、创伤导致的组织水肿而引起的气道阻塞,有一定程度的非特异性抑制作用,抗炎作用直接与局部炎症组织中类固醇的浓度成比例。不同病例的疗效,取决于剂量、损伤的严重性、组织反应和是否合并先天性气道狭窄的情况。喉气管支气管炎(LTB):对类固醇治疗LTB的疗效争论较大。作者复习1960年以来部分文献,虽无明确结论,但总的认为可改善症状,且疗效高低与剂量大小相平行。
Adrenocortical steroids have a strong inhibitory effect on the inflammatory response. Because steroids can maintain the integrity of the vascular endothelial cells, to prevent increased vascular permeability can reduce the leakage to the tissue; to maintain cell membrane integrity and lysosomal membrane integrity, to prevent its release after the release of acid hydrolysis enzyme enzyme; and inhibit damaged tissue Can further undermine the phagocytosis of tissue, so the inflammation, allergy, trauma caused by tissue edema caused by airway obstruction, there is a certain degree of non-specific inhibition of anti-inflammatory effect directly with the local inflammation of the steroid concentration into proportion. The efficacy of different cases depends on the dose, the severity of the injury, the tissue response, and the presence or absence of congenital airway stenosis. Laryngeal-tracheal bronchitis (LTB): A debate over the efficacy of steroids in the treatment of LTB. The authors review some of the literature since 1960, although no clear conclusion, but the general view that can improve the symptoms, and the level of efficacy and dose parallel.