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目的:探讨血清胱抑素C(Cys C)与乙型肝炎性肝硬化患者肝功能损伤程度的相关性分析。方法:将98例乙型肝炎性肝硬化患者按照肝功能分级的Child-Pugh评分将分为A组(Child A级,n=45例)、B组(Child B级,n=33例)、C组(Child C级,n=20例),同期选取本院门诊正常健康体检者为对照组,检测所有受试者的血清Cys C水平,比较各种之间相关指标的差异。结果:A组、B组、C组、对照组丙氨酸氨基转移酶(ALT)、天门冬氨酸转移酶(AST)、血清白蛋白(ALB)、血清Cys C及血清Cys C阳性率均有统计学差异(P<0.05),C组血清Cys C、血清Cys C阳性率高于对照组(P<0.05)、A组、B组,而B组高于对照组、A组(P<0.05);血清Cys C阳性组与阴性组中含有Child A级、Child B级、Child C级患者的构成比具有统计学意义(P<0.05),Cys C阳性组中的Child C级患者比例高于阴性组(P<0.05);血清Cys C与Child-Pugh评分呈正相关(P<0.05);Child-Pugh评分、ALT、AST与患者血清Cys C阳性呈正相关(P<0.05);而ALB则与其呈负相关(P<0.05);结论:乙型肝炎性肝硬化患者血清Cys C水平与肝功能损伤程度呈一定相关性,早期检测血清Cys C水平对于评估乙型肝炎性肝硬化患者的肝功能损害具有一定的临床意义。
Objective: To investigate the correlation between serum cystatin C (Cys C) and liver injury in patients with hepatitis B cirrhosis. Methods: A total of 98 patients with hepatitis B cirrhosis were divided into group A (Child A grade, n = 45) and group B (Child B grade, n = 33) according to Child-Pugh score of liver function. Group C (Child C grade, n = 20). At the same period, normal outpatients were selected as the control group. Serum levels of Cys C were detected in all subjects, and the differences among various indexes were compared. Results: The positive rates of ALT, AST, Cys C and Cys C in group A, B, C and control were (P <0.05). The positive rates of serum Cys C and Cys C in group C were higher than those in control group (P <0.05), group A and group B, while those in group B were higher than those in control group and group A (P < 0.05). The proportions of Child A, Child B and Child C patients in the serum Cys C positive and negative groups were statistically significant (P <0.05), and the proportion of Child C Cys positive patients was high (P <0.05). Child-Pugh score, ALT and AST were positively correlated with serum Cys C (P <0.05), but ALB (P <0.05). CONCLUSIONS: The serum Cys C level in patients with hepatitis B cirrhosis is correlated with the severity of liver injury. The early detection of serum Cys C levels is of great value in the assessment of the liver of patients with hepatitis B cirrhosis Functional impairment has some clinical significance.