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目的 评价新型封堵器堵闭动脉导管的可行性、安全性和有效性。方法 将Baxter聚四氟乙烯 (PTEF)带环人造血管缝合在犬降主动脉和左肺动脉之间建立动脉导管未闭动物模型 ,3～ 6d后经皮穿刺封堵动脉导管。术后 1周、1个月、6个月行大体解剖 ,组织学及扫描电镜检查。结果 5只犬成功建立了动物模型 ,5只模型犬均堵闭成功 ,无残余分流。术后 1个月封堵器表面部分由内皮组织覆盖 ,术后 6个月封堵器两端完全为一层内皮组织覆盖。结论 新型动脉导管未闭封堵器堵闭实验性动脉导管未闭安全、有效。
Objective To evaluate the feasibility, safety and effectiveness of the new occluder in blocking the ductus arteriosus. Methods Arteriosus was implanted with a Baxter polytetrafluoroethylene (PTEF) loop graft to establish a patent ductus arteriosus model between the descending aorta and left pulmonary artery in dogs. Percutaneous catheter occlusion was performed 3 to 6 days later. One week, one month and six months after operation, gross anatomy, histology and scanning electron microscopy were performed. Results Five dogs successfully established animal models. All five dogs were blocked successfully without residual shunt. One month after operation, the surface of the occluder was partially covered by endothelial tissue. Both ends of the occluder were completely covered with endothelial tissue 6 months after operation. Conclusions The new patent ductus arteriosus occluder blocking the patent ductus arteriosus is safe and effective.