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目的分析哮喘患者长期吸入丙酸氟替卡松治疗对于肾上腺皮质功能和疗效的影响。方法选取90例哮喘患者作为研究对象。中度和重度病例分别为49例、41例,对中度病例采取丙酸氟替卡松气雾剂每日500μg规格治疗,重度病例实施每日规格为750μg的治疗方案。在治疗结束时,测定患者的FEV1%以及PEF,以及实施测定清晨8时的血浆皮质醇情况,统计总体治疗有效率。结果无论中度组吸入丙酸氟替卡松500μg,还是重度组吸入丙酸氟替卡松750μg,他们血浆皮质醇值在治疗前后无显著差异性,P>0.05;在进行吸入丙酸氟替卡松治疗1年以后,患者的血浆皮质醇值均在正常范围内;观察总体治疗有效率,组间比较无显著差异性。结论对于中度、重度哮喘病例而言,采取长期每天吸入500μg与每天吸入750μg的效果相当,均能够得到良好成效,同时不对肾上腺皮质功能产生显著性的抑制效果。
Objective To analyze the effect of long-term inhaled fluticasone propionate treatment on the function and efficacy of adrenal cortex in asthmatic patients. Methods 90 asthmatic patients were selected as the research object. Moderate and severe cases were 49 cases, 41 cases, for moderate cases of fluticasone propionate aerosol daily treatment 500μg specifications, severe cases of the implementation of the daily specifications for the treatment of 750μg. At the end of treatment, the patient’s FEV 1% and PEF were measured, and plasma cortisol was measured at 8:00 AM. The overall response rate was calculated. Results No significant difference was found in the plasma cortisol level between the two groups (P> 0.05) after one week of fluticasone propionate treatment, no matter whether they received inhalation of fluticasone propionate 500μg in the moderate group or fluticasone propionate 750μg in the severe group Plasma cortisol values were within the normal range; observe the overall treatment efficiency, no significant difference between groups. CONCLUSIONS: For moderate and severe cases of asthma, long-term daily inhalation of 500 μg is equivalent to inhalation of 750 μg daily, with good results achieved without significant inhibitory effects on adrenocortical function.