神经生长因子(Nerve Growth Factor,简称 NGF)系1951年 Levi-Montalcini 发现。大量的体内外实验证明,它对交感神经细胞和感觉神经细胞有促进成熟与分化的作用。NGF 广泛存在于动物体内,以成年雄性小鼠颌下腺中含量最高,其次是豚鼠前列腺和蛇毒中。它为一蛋白质,分子量130000,通常称为7S NGF,由5个亚基组成,只有β亚基具有促进神经生长的特性。用不同方法提取,可 Nerve growth factor (NGF) was discovered in 1951 by Levi-Montalcini. A large number of in vitro and in vivo experiments show that it can promote the maturation and differentiation of sympathetic and sensory nerve cells. NGF is widely present in animals, with the highest content in the submandibular glands of adult male mice followed by the guinea pig prostate and snake venom. It is a protein with a molecular weight of 130,000, commonly referred to as 7S NGF, composed of five subunits, with only the beta subunit having the property of promoting nerve growth. Extract with different methods