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目的：观察氢化可的松联合帕瑞昔布钠减轻支撑喉镜下声带手术后咽痛的临床效果。方法选择拟行显微镜下支撑喉镜声带手术患者90例，随机分为A组（氢化可的松2.5 mg／kg ）、B组（帕瑞昔布钠40 mg ）和C组（氢化可的松＋帕瑞昔布钠）。麻醉前20min静脉给予相应药物，分别记录拔管后5、15、30、60、120min各时间点的心率（HR）和平均动脉压（MAP）。拔管后2h、12h和24h对3组咽痛程度采用VAS疼痛评分评价。结果 C组患者拔管后的MAP和HR显著低于A组和B组，差异有统计学意义（ P＜0.05）， A组与B组差异无统计学意义（ P＞0.05）。拔管后2h、12h和24h的VAS疼痛评分C组显著低于A、B组，差异有统计学意义（P＜0.05），A组与B组差异无统计学意义（ P＞0.05）。未发现静脉使用氢化可的松及帕瑞昔布钠相关的并发症。结论氢化可的松联合帕瑞昔布钠能显著降低支撑喉镜术后咽痛的发生率及严重程度。“,”Objective To study effect of hydrocortisone combined with parecoxib on prevention of sore throat after vo -cal cord polyp excision by micro -suspension laryngoscope .Methods A total of 90 cases of such patients randomly divided into A group(hydrocortisone 2.5mg/kg),B group(parecoxib 40mg)and C group (hydrocortisone combined with parecoxib ). Three groups were given the corresponding drug 20 mins before induction of anesthesia .The heart rate ( HR) and mean arterial pressure (MAP) were recorded at 5、15、30、60、120min after extubation.The analgesic effect assessed by Visual analgesia scale (VAS) at 2h,12h and 24h after extubation.Results The HR and MAP in C group was lower than that in A and B group(P0.05).VAS in C group was lower than that in A and B group ( P0.05 ) .Con-clu sion Hydrocortisone combined with parecoxib can reduce the incidence and severity of sore throat after vocal cord polyp excision by micro-suspension laryngoscope .