自1943年Mac Leod首次提出活性氧(ROS)的产生可使精子迅速失去活力以来,氧自由基在男性生殖中的作用越来越受到人们的重视。近年来,国内外越来越多的研究发现,ROS不仅与精子高活跃性运动获能、顶体反应等生理功能有关,还与精子活力降低、DNA氧化损伤等病理作用有联系,ROS的产生可致使男性不育。本研究就ROS与男性不育的相关研究进展进行以下综述。1线粒体介导的ROS的产生 Since Mac Leod first proposed in 1943 that the production of reactive oxygen species (ROS) can rapidly lose sperm motility, the role of oxygen free radicals in male reproduction has drawn more and more attention. In recent years, more and more researches at home and abroad have found that ROS is not only related to the high activity of sperm motility, acrosome reaction and other physiological functions, but also to the reduction of sperm motility, DNA oxidative damage and other pathological effects, ROS generation Can cause male infertility. In this study, we reviewed the research progress of ROS and male infertility. 1 mitochondria-mediated ROS production