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系统性硬皮病(SSD)属于弥漫性结缔组织疾病,有广泛的纤维硬化性病变和明显的微循环床病变。由于微循环障碍,组织缺氧,因而导致硬化性病变发展。作者研究高压氧综合治疗 SSD 时微循环的变化。用高压氧治疗Ⅱ～Ⅲ期 SSD 25例(女24例,男1例),平均年龄35±3.4岁。病程3～15年。高压氧舱压力1.3～1.7ATA,治疗30～40min,疗程10～12次,治疗前和第1次治疗后以及疗程结束时,用裂隙灯活体显微镜检查结膜的微循环情况,用寻常光和绿光,放大30～60倍,并进行显微照相,评定微血管、血管内和血管外的变化。同时根据雷诺征,患肢皮肤营养障碍等 SSD 的临床表现来判断微循环情况。
Systemic scleroderma (SSD) is a diffuse connective tissue disease, a wide range of fibrosis sclerosis and significant microcirculation bed lesions. Due to microcirculation, tissue hypoxia, which led to the development of sclerosis. Authors study the changes of microcirculation in the treatment of SSD with hyperbaric oxygen. With hyperbaric oxygen treatment Ⅱ ~ Ⅲ SSD 25 cases (24 females, 1 male), mean age 35 ± 3.4 years old. Duration of 3 to 15 years. Hyperbaric oxygen chamber pressure 1.3 ~ 1.7ATA, treatment of 30 ~ 40min, the treatment of 10 to 12 times before and after treatment and the end of treatment, the slit lamp microscope examination of the microcirculation of the conjunctiva with ordinary light and green Light, magnified 30 to 60 times, and subjected to photomicrographs to assess microvascular, intravascular and extravascular changes. At the same time according to Renault levy, limb skin disorders such as the clinical manifestations of SSD to determine the microcirculation.