革兰氏阴性(G~-)杆菌是新生儿脑膜炎的主要致病菌,除新生儿外,由该菌引起的脑膜炎相对较少,但有增加趋势。新生儿和婴儿由革兰氏阴性肠道杆菌(GNEB)引起的脑膜炎的全面情况尚未很好地描述过。为此该文作者回顾21年来对危重病儿的确诊、诱发因素、临床及实验室检查、并发症和治疗方法及新生儿和婴儿的不同等方面的经验。98例GNEB脑膜炎中96例脑脊液(CSF)培养阳性,2例血培养阳性伴化脓性CSF。7例有复发。GNEB是脑膜炎第5位最常见的致病菌。72例在新生儿期发病,其中半数年龄<7天,26例>1个月,8例>3个月,最小出生20小时,最大26个月。埃希氏大 Gram-negative (G ~ -) bacilli are the main pathogens of neonatal meningitis, except for newborns, the meningitis caused by the bacteria is relatively small, but there is an increasing trend. The comprehensive picture of meningitis caused by gram-negative enterobacter (GNEB) in neonates and infants is not well described. To this end, the authors review the 21 years of diagnosis of critically ill children, predisposing factors, clinical and laboratory tests, complications and treatment methods and newborns and infants different experience. In 98 cases of GNEB meningitis, 96 cases of cerebrospinal fluid (CSF) culture positive, 2 cases of blood culture positive with purulent CSF. Seven patients had recurrence. GNEB is the fifth most common cause of meningitis. 72 cases in the neonatal morbidity, of which half the age of <7 days, 26 cases> 1 month, 8 cases> 3 months, the minimum birth 20 hours, maximum 26 months. Essy big