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目的探讨炎琥宁对感染性心内膜炎(IE)患儿治疗效果及对血清降钙素原(PCT)、超敏C-反应蛋白(hsCRP)及血沉(ESR)的影响,以期为临床治疗提供依据。方法选取2014年1月-2015年12月医院收治IE患儿86例,随机分为观察组44例,对照组42例,对照组给予药敏试验敏感药物及对症治疗,观察组在对照组基础上给予炎琥宁联合干扰素治疗,于治疗前后进行PCT、hs-CRP、ESR测定,观察两组治疗前后各项指标变化,观察治疗7d临床效果。结果观察组患儿治疗后PCT、hs-CRP、ESR与本组治疗前及对照组同指标对比,差异有统计学意义(P<0.05);经7d治疗,观察组总有效率95.45%高于对照组76.19%,差异有统计学意义(P<0.05)。结论综合治疗基础上给予炎琥宁可有效改善IE患儿CRP、PCT及ESR指标,提高治疗效果,且不良反应低下。
Objective To investigate the therapeutic effect of Yanhu Ning on children with infective endocarditis (IE) and its effect on serum procalcitonin (PCT), high sensitivity C-reactive protein (hsCRP) and erythrocyte sedimentation rate (ESR) Provide the basis for treatment. Methods From January 2014 to December 2015, 86 children with IE were randomly divided into observation group (n = 44) and control group (n = 42). The control group was given sensitive drugs and symptomatic treatment. The observation group was basal in control group On the combination of Yan Hu Ning interferon treatment before and after treatment of PCT, hs-CRP, ESR were measured before and after treatment to observe the changes of the two indicators to observe the clinical effect of treatment 7d. Results The PCT, hs-CRP and ESR in the observation group were significantly different from those in the control group before and after treatment (P <0.05). After 7 days of treatment, the total effective rate in the observation group was 95.45% The control group 76.19%, the difference was statistically significant (P <0.05). Conclusion Yan Hu Ning can effectively improve the CRP, PCT and ESR indexes of children with IE, and improve the therapeutic effect with low adverse reactions.