Miller Fisher综合征(MFS)是一种急性多发性神经病,是格林·巴利综合征(GBS)的一种变型,在临床上以急性眼肌麻痹、共济失调、反射减弱三联症为特征。MFS在免疫病源学方面已取得重要的进展。常与GQ1b抗体水平升高有关,常伴有前驱的空肠弯曲菌感染。但有关MFS是属于轴索性的还是脱髓鞘性的多神经病,以及GBS的另一种变型——共济失调性GBS是否存在与MFS不同的病理生理学特征,目前还存在争议。 Miller Fisher syndrome (MFS) is an acute polyneuropathy, a variant of GBS, clinically characterized by ocular ophthalmoplegia, ataxia, and reflex-induced triad. MFS has made important advances in immunopathology. Often associated with elevated levels of GQ1b antibodies, often accompanied by a precursor of Campylobacter jejuni infection. However, there is still controversy about whether or not MFS is axonal or demyelinating polyneuropathy, and whether there is a different pathophysiological feature of ataxia GBS in ataxia GBS, another variant of GBS.