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目的:探讨新辅助化疗对乳腺癌ER、PR、C_erbB_2、p53表达的影响。方法:采用免疫组化Envision法,检测91例乳腺癌患者新辅助化疗前后ER、PR、C_erbB_2、p53的表达。结果:新辅助化疗前后ER、PR、C_erbB_2、p53表达状态发生改变的分别有15、20、12、17例,新辅助化疗前后ER、PR、C_erbB_2、p53的表达无显著性差异(P>0·05)。结论:新辅助化疗能使部分乳腺癌组织中ER、PR、C_erbB_2、p53的表达发生变化,但新辅助化疗对ER、PR、C_erbB_2、p53表达状态无显著影响。
Objective: To investigate the effect of neoadjuvant chemotherapy on the expression of ER, PR, C_erbB_2 and p53 in breast cancer. Methods: The expression of ER, PR, C_erbB_2 and p53 in 91 cases of breast cancer patients before and after neoadjuvant chemotherapy were detected by immunohistochemistry Envision method. Results: The expressions of ER, PR, C_erbB_2 and p53 in neoadjuvant chemotherapy before and after neoadjuvant chemotherapy were 15, 20, 12 and 17 cases respectively. The expression of ER, PR, C_erbB_2 and p53 had no significant difference before and after neoadjuvant chemotherapy (P> 0 · 05). CONCLUSION: Neoadjuvant chemotherapy can change the expression of ER, PR, C_erbB_2 and p53 in some breast cancer tissues. Neoadjuvant chemotherapy has no significant effect on the expression of ER, PR, C_erbB_2 and p53.