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骨关节结核是一种由结核分枝杆菌引起的感染性骨科疾病,致畸率和致残率均较高。骨关节结核可导致关节疼痛、关节畸形等,甚至可引起瘫痪,严重影响患者生活质量。骨关节结核的发病机制与环境因素、遗传因素等有关,但目前尚无定论。基因多态性是遗传因素中不可缺少的部分,参与骨关节结核的发生。本文就骨关节结核的易感性与相关基因多态性的研究进展作一综述。
Osteoarticular tuberculosis is an infectious orthopedic disease caused by Mycobacterium tuberculosis, teratogenic and morbidity rates are high. Osteoarthritis tuberculosis can lead to joint pain, joint deformities, etc., can even cause paralysis, seriously affecting the quality of life of patients. The pathogenesis of osteoarticular tuberculosis and environmental factors, genetic factors, etc., but there is no conclusion. Genetic polymorphism is an indispensable part of genetic factors involved in the occurrence of bone and joint tuberculosis. This article reviews the research progress of susceptibility to osteoporosis and related genetic polymorphisms.