新生儿缺氧缺血性脑病(Hypoxic-ischemic encephalopathy,HIE)是新生儿期危害性最大的常见病之一,常引起新生儿急性死亡和慢性神经系统损伤。是新生儿死亡和致残的重要因素之一。在HIE的发病过程中,炎症因子起到很大的作用,临床上检测患儿血清中与HIE相关的白细胞介素(Interleukin,IL),为新生儿HIE的诊断及预后的判断提供新的理论基础。本文论述了在新生儿缺氧缺血性脑病中损伤性及保护性白细胞介素的作用机制。 Hypoxic-ischemic encephalopathy (HIE) is one of the most common and common neonatal diseases. It often causes neonatal acute death and chronic nervous system injury. It is one of the important factors in neonatal death and disability. In the pathogenesis of HIE, inflammatory cytokines play a significant role in the clinical detection of HIE-related children with serum interleukin (Interleukin, IL), for neonatal HIE diagnosis and prognosis to provide a new theory basis. This article discusses the mechanism of damaging and protective interleukins in neonatal hypoxic-ischemic encephalopathy.