论文部分内容阅读
目的探讨寻求伴一系或多系病态造血的儿童急性髓系白血病治疗方案,以期在短时间内达到完全缓解,为长期无病生存打下基础。方法对DA或HA标准方案治疗1、2个疗程,无效的10例一系或多系病态造血的急性髓性白血病患儿采用自身对照的方法。第2疗程化疗均采用米托蒽醌、依托泊苷、阿糖胞苷(MEA)方案,并辅以抗感染、成分输血、细胞因子应用等治疗。结果10例患儿MEA方案治疗1个疗程,治疗中骨髓抑制期最长达19 d。中性粒细胞绝对值0～0.08×109L-1,血小板(6～10)×109L-1,白细胞升至3.5×109L-1时,骨髓原始细胞8例下降至0.05以下,血小板恢复正常,Hb升高,8例获完全缓解,2例无效。结论用MEA方案治疗伴一系或多系病态造血的急性髓系白血病儿童患者疗效较好。
Objective To explore the treatment of acute myeloid leukemia in children with one or more lines of pathological hematopoiesis, in order to achieve complete remission in a short period of time and lay the foundation for long-term disease-free survival. Methods DA or HA standard regimen of 1, 2 courses of treatment, and invalid 10 cases of one or more lines of pathological hematopoietic children with acute myeloid leukemia using self-control method. The second course of chemotherapy are mitoxantrone, etoposide, cytarabine (MEA) program, supplemented by anti-infective, component transfusion, cytokine therapy. Results MEA regimen in 10 patients treated for 1 course of treatment in the treatment of bone marrow suppression up to 19 days. Neutrophils absolute value of 0 ~ 0.08 × 109L-1, platelets (6 ~ 10) × 109L-1, white blood cells rose to 3.5 × 109L-1, bone marrow blast cells in 8 cases decreased to below 0.05, platelets returned to normal, Hb Elevated, 8 patients were completely relieved, 2 patients were ineffective. Conclusion The MEA regimen is effective in treating children with acute myeloid leukemia with one or more lines of pathological hematopoiesis.