目的和方法 :采用流式细胞仪检测淋巴细胞亚群法 ,探讨米非司酮对早孕外周血和蜕膜NK细胞亚群的影响。结果 :早孕和米非司酮处理组外周血的NK细胞各亚群的百分率近似 ;米非司酮处理组血清E2和P4 均稍高于早孕组。而早孕蜕膜组的三个NK细胞亚群的百分率均明显高于米非司酮处理组。米非司酮处理组的蜕膜以CD5 6 +NK细胞为主要淋巴细胞亚群 ,而外周血则以CD5 6 +CD16 +和CD16 +NK细胞为主。结论 :米非司酮主要作用于早孕母胎界面 ,阻断蜕膜CD5 6 +NK细胞的增殖和分化 ,诱导胎儿免疫排斥 PURPOSE AND METHODS: The effect of mifepristone on NK cell subsets of peripheral blood and decidua in early pregnancy was investigated by flow cytometry assay of lymphocyte subsets. Results: The percentages of NK cells in peripheral blood of the first trimester and mifepristone treatment groups were similar. The levels of E2 and P4 in the mifepristone group were higher than those in the first trimester group. The percentage of three NK cell subsets in early pregnancy decidua group were significantly higher than those in mifepristone group. In the mifepristone treatment group, the majority of decidual cells were CD56 + NK cells, while the peripheral blood was mainly CD56 + CD16 + and CD16 + NK cells. Conclusion: Mifepristone mainly acts on the interface of maternal-fetal cells in early pregnancy, blocking the proliferation and differentiation of decidual CD56 + NK cells and inducing fetal immune rejection