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测定了72例早、晚期肝硬化,20例肝癌和98例正常人血清中铜、锌、镉、锰含量,经Apple-Ⅱ型计算机统计分析,结果表明:早晚期肝硬化、肝癌患者血清中铜、锌、镉、锰、铜/锌和镉/锌比与对照组均有显著差异(P<0.01),且铜、锌、锰、镉/锌比在三组病人之间也有显著差异(P<0.001)。4种元素,两个比值单因素相关分析表明血清铜与锌呈高度正相关(γ=0.684),锰与铜、锌呈高度负相关(γ=-0.3233,-0.4013)。但经多因素逐步判别分析表明只有铜、锰与肝硬化进展和癌变有相关关系。即肝癌时血清铜最高,血清锰最低。
The serum levels of copper, zinc, cadmium and manganese in 72 cases of early and late cirrhosis, and 20 cases of hepatocellular carcinoma and 98 normal persons were determined. The results were statistically analyzed by the Apple-II type computer. The results showed that: in the serum of patients with liver cirrhosis and liver cancer. The copper, zinc, cadmium, manganese, copper/zinc, and cadmium/zinc ratios were significantly different from the control group (P<0.01), and the copper, zinc, manganese, and cadmium/zinc ratios were also significantly different among the three groups of patients (P<0.01). P<0.001). The analysis of four factors and two ratios of single factors showed that serum copper and zinc were highly positively correlated (γ=0.684), and manganese was highly negatively related to copper and zinc (γ=-0.3233, -0.4013). However, multi-factor stepwise discriminant analysis showed that only copper, manganese and liver cirrhosis progression and cancer are related. That is, serum copper is the highest in liver cancer, and serum manganese is the lowest.