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目的观察噻托溴铵对老年慢性阻塞性肺疾病(COPD)稳定期患者气道重构及肺功能的影响。方法将老年COPD稳定期患者86例按照随机数字表法分为观察组43例和对照组43例,对照组给予常规治疗,观察组在对照组基础上加用噻托溴铵治疗,比较2组患者治疗前后气道重构及肺功能相关指标。结果治疗前2组患者气道重构及肺功能指标比较差异无统计学意义(P>0.05),治疗后2组均有好转,且观察组改善程度优于对照组,差异均有统计学意义(P<0.05)。结论噻托溴铵治疗老年COPD可有效缓解患者气道重构,促进肺功能改善,提高治疗效果,值得临床广泛推广。
Objective To investigate the effect of tiotropium on airway remodeling and pulmonary function in elderly patients with stable chronic obstructive pulmonary disease (COPD). Methods 86 elderly patients with stable COPD were randomly divided into observation group (43 cases) and control group (43 cases). The control group was given routine treatment. The observation group was treated with tiotropium on the basis of the control group. Airway remodeling and pulmonary function related indicators before and after treatment in patients. Results There was no significant difference in airway remodeling and pulmonary function between the two groups before treatment (P> 0.05). After treatment, both groups improved, and the improvement in the observation group was better than that in the control group, the differences were statistically significant (P <0.05). Conclusion Tiotropium treatment of elderly patients with COPD can effectively relieve airway remodeling, improve pulmonary function and improve the therapeutic effect, it is worth widely clinical promotion.