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在低硒饲料条件下，以５０ｍｇ／Ｌ榆林大骨节病区黄腐酸（ＦＡ）饮水和ＫＢＤ新发户井水１０倍浓缩饮水分别致雏鸡ＫＢＤ模型实验３７天。前一组鸡每只每天摄入ＦＡ２．０ｍｇ，等于１０．０ｍｇ·ＦＡ／ｋｇＢＷ·ｄ，该剂量约为该病区儿童每公斤体重摄入量的１０００倍。上述两类饮水对两实验组的全身一般状况，部分相关生化指标，肝、心、肾等乃至骨软骨都未能显示任何有害作用，即未能导致雏鸡类似ＫＢＤ的任何病变。另以１００ｍｇ·病区ＦＡ／Ｌ饮水（剂量１０．０ｍｇ·ＦＡ／ｋｇＢＷ·ｄ）致大鼠ＫＢＤ模型实验２８天，其结果与雏鸡的完全一致
Under low-selenium diet, chondroitin sulfate (FA) drinking water of 50mg / L Yulin Kashin-Beck disease area and 10 times concentrated drinking water of KBD newcomer well water were used to induce KBD model of chickens for 37 days respectively. The former group of birds consumed FA 2.0 mg daily, equivalent to 10.0 mg · FA / kg BW · d, which is about 1000 times the body weight intake of children in this ward. The two types of drinking water on the two general experimental group general condition, some related biochemical indicators, liver, heart, kidney and even osteochondral failed to show any harmful effects, that is, did not lead to any lesions similar to the KBD chicken. Another 100 mg · ward FA / L drinking water (dose 10.0mg · FA / kgBW · d) induced KBD model rats for 28 days, the results are exactly the same with chickens