小鼠口服最大耐受量测定表明全龟胶囊单次和每日３次给药最大耐受量分别为４０ｇ／ｋｇ·ｄ－１和１２０ｇ／ｋｇ·ｄ－１；大鼠连续口服全龟胶囊（２和２０ｇ／ｋｇ·ｄ－１）９０ｄ及停药２１ｄ期间，对生长发育、造血功能、肝肾功能、血糖、胆固醇、器官组织等均无明显毒性。提示全龟胶囊临床用药量极为安全，无毒性 The maximum oral tolerance test in mice showed that the maximum tolerated dose of the whole tortoise capsule was 40g / kg · d-1 and 120g / kg · d-1 in single and three times a day, respectively. (2 and 20g / kg · d-1) 90d and withdrawal 21d, there was no obvious toxicity on the growth and development, hematopoietic function, liver and kidney function, blood glucose, cholesterol, organ tissue and so on. Tip of the whole turtle capsule clinical dosage is extremely safe, non-toxic