氧化应激在高体积分数氧(高氧)肺损伤中起极其重要的作用。大量活性氧在肺组织内蓄积,不仅可通过直接细胞毒性作用损伤肺组织细胞,而且可作为炎性细胞因子的转录调节信号分子诱发炎性反应、细胞凋亡等加重肺损伤。现就氧化应激及其引发的炎性反应、细胞凋亡等在高氧肺损伤病理过程中的作用作一综述。 Oxidative stress plays an extremely important role in the high volume fraction of oxygen (hyperoxia) lung injury. A large number of reactive oxygen species accumulated in the lung tissue, not only through the direct cytotoxic effect of lung tissue damage cells, but also as a transcription factor of inflammatory cytokines induced inflammatory response, apoptosis and other aggravating lung injury. Now on the oxidative stress and its induced inflammatory response, apoptosis and so on in the pathogenesis of hyperoxic lung injury in the role of are reviewed.